Table III.

NCI-CTC v.3.0 grade 2 or above adverse events.

Adverse events	Gr2	Gr3	Gr4	%
S-1 group
Leukopenia	2	0	0	10.5
Neutropenia	1a	0	0	5.2
Fatigue	3	0	0	15.7
Vomiting	2	0	0	10.5
Diarrhea	0	1a	0	5.2
Stomatitis	13	1	0	73.7
Elevation of bilirubin level	1	0	0	5.2
AI group
Hypochromia	2	0	0	14.2
Leukopenia	2	0	0	14.2
Neutropenia	1	1	0	14.2
Thrombocytopenia	1	0	0	7.1
Fatigue	3	0	0	21.4
Nausea	2	0	0	14.2
Vomiting	0	1	0	7.1
Stomatitis	12	0	0	57.1
Soft tissue impairment	1b	1c	0	9.5

^aWithdrawal of S-1;

^bpharyngeal edema;

^cpharyngeal necrosis.

S-1, concurrent neoadjuvant chemoradiotherapy with S-1 and a total external irradiation dose of 30 Gy; AI, concurrent neoadjuvant chemoradiotherapy using super-selective intra-arterial infusion with cisplatin or carboplatin and a total external irradiation dose of 40 Gy; NCI-CTC, National Cancer Institute’s Common Toxicity Criteria.