Table 1.

Occurrence of Ras and B-Raf in human cancers. Data derived from COSMIC database; http://www.sanger.ac.uk/genetics/CGP/cosmic.

Tissue	K-Ras	N-Ras	H-Ras	BRAF
Biliary tract	32%	1%	0%	14%
Bone	1%	0%	2%	0%
Breast	5%	1%	1%	2%
CNS	1%	2%	0%	3%
Cervix	8%	1%	9%	1%
Endometrium	14%	0%	1%	1%
GI tract (site indeterminate)	19%	0%	0%	0%
Haematopoietic and	5%	12%	0%	2%
Lymphoid tissue
Kidney	1%	0%	0%	0%
Large intestine	32%	3%	0%	13%
Liver	7%	4%	0%	3%
Lung	17%	1%	0%	2%
Melanoma	1%	17%	1%	64%
Oesophagus	4%	0%	0%	2%
Ovary	15%	4%	0%	13%
Pancreas	60%	2%	0%	2%
Prostate	8%	1%	6%	6%
Salivary gland	4%	0%	16%	0%
Skin *	2%	19%	5%	41%
Small intestine	20%	25%	0%	5%
Soft tissue	12%	6%	7%	3%
Stomach	6%	2%	4%	1%
Testis	5%	4%	0%	0%
Thyroid	3%	7%	4%	37%
Urinary tract	4%	3%	12%	0%

^*skin cancers including melanoma.