Table 4.
Multivariate Hazard Ratios for Self-Reported Incident Mobility Limitation by Time-Varying Statin Exposure
| Variables | Age- & Sex- Adjusted HR (95%CI) |
Fully Adjusted* HR (95%CI) |
|---|---|---|
| Any statin use | 1.08 (0.94, 1.24) | 1.02 (0.87, 1.17) |
| Non- use | 1.00 (reference) | 1.00 (reference) |
| Dose | ||
| > 1 SDD | 1.13 (0.84, 1.52) | 0.97 (0.71, 1.32) |
| 1 SDD | 1.10 (0.89, 1.35) | 1.08 (0.87, 1.33) |
| < 1 SDD | 1.06 (0.87, 1.28) | 0.98 (0.80, 1.20) |
| Non- use | 1.00 (reference) | 1.00 (reference) |
| Duration | ||
| Long term use (> 2 yrs) | 1.00 (0.85, 1. 18) | 0.94 (0.79 , 1.12) |
| Short term use (< 2 yrs) | 1.25 (1.01, 1.54) | 1.15 (0.93, 1.42) |
| Non- use | 1.00 (reference) | 1.00 (reference) |
*
Model adjusted for baseline sociodemographics (race, age, gender, education, living status), health behaviors (smoking, alcohol), and health status (hypertension, pulmonary disease, peripheral arterial disease, urinary problems, vision problems, fair/poor self-related health, body mass index, use of diuretics, digoxin, CNS medications, ACE-inhibitors and total number of medications). Models included time-varying statin use, stroke, MI, heart failure, diabetes, depressive symptoms and cognitive impairment.
SDD=standardized daily dose