Table 5.
Multivariate Hazard Ratios for Self-Reported Incident Mobility Limitation by Time-Varying ACE Inhibitor and Statin Exposure
| Variables | Age- & Sex- Adjusted HR (95%CI) |
Fully Adjusted* HR (95%CI) |
|---|---|---|
| ACE use only | 1.38 (1.18, 1.60) | 1.02 (0.87, 1.19) |
| Statin use only | 1.18 (1.01, 1.38) | 1.23 (0.96, 1.33) |
| ACE and statin Use | 1.05 (0.81, 1.37) | 0.77 (0.59, 1.01) |
| No ACE or statin use | 1.00 (reference) | 1.00 (reference) |
*
Model adjusted for baseline sociodemographics (race, age, gender, education, living status), health behaviors (smoking, alcohol), and health status (hypertension, pulmonary disease, peripheral arterial disease, urinary problems, vision problems, fair/poor self-related health, body mass index, use of diuretics, digoxin, CNS medications and total number of medications). Models included time-varying ACE-inhibitor use, statin use, stroke, MI, heart failure, diabetes, depressive symptoms and cognitive impairment.
SDD=standardized daily dose