Table 2.
Genes differentially expressed between BMSCs and hES
| Genes up-regulated in BMSCs | Fold- Increase | Genes down-regulated in BMSCs | Fold- Decrease | ||
|---|---|---|---|---|---|
| TGFBI | transforming growth factor, beta-induced, 68kDa | 298 | SLC7A3 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 | 48.8 |
| ADAM12 | ADAM metallopeptidase domain 12 | 82.8 | TERF1 | telomeric repeat binding factor (NIMA-interacting) 1 | 32.6 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 61.4 | psiTPTE22 | TPTE pseudogene (psiTPTE22) | 30.1 |
| CERCAM | cerebral endothelial cell adhesion molecule | 59.9 | psiTPTE22 | TPTE pseudogene (psiTPTE22) | 29.2 |
| COL5A1 | collagen, type V, alpha 1 | 56.3 | POU5F1B | POU class 5 homeobox 1B | 25.8 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 51.3 | O00627 | Endogenous retrovirus H D1 leader region/integrase- derived ORF1 ORF2, and putative envelope protein | 22.8 |
| TSPO | translocator protein (18kDa), | 49.7 | CCND2 | cyclin D2 | 14.7 |
| CRIP2 | cysteine-rich protein 2 | 39.1 | LEFTY1 | left-right determination factor 1 | 13.8 |
| MYOF | myoferlin | 31.0 | FAM60A | family with sequence similarity 60, member A | 13.5 |
| COMT | catechol-O-methyltransferase | 30.0 | CDH3 | cadherin 3, type 1, P-cadherin | 13.4 |
| THBS2 | thrombospondin 2 | 30.0 | JARID2 | jumonji, AT rich interactive domain 2 | 13.2 |
| TNS1 | tensin 1 | 28.9 | TUBB2B | tubulin, beta 2B | 12.6 |
| IAH1 | isoamyl acetate-hydrolyzing esterase 1 homolog | 27.2 | HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 12.3 |
| TSPO | translocator protein (18kDa) | 27.3 | PLCXD1 | phosphatidylinositol-specific phospholipase C, X domain containing 1 | 11.4 |
| ALPK2 | alpha-kinase 2 | 27.1 | CD24 | CD24 molecule | 10.9 |
| EMILIN1 | elastin microfibril interfacer 1 | 25.4 | TRIM24 | tripartite motif-containing 24 | 10.8 |
| MVP | major vault protein | 24.7 | GARNL4 | GTPase activating Rap/RanGAP domain-like 4 | 10.5 |
| CCDC92 | coiled-coil domain containing 92 | 24.6 | FXYD6 | FXYD domain containing ion transport regulator 6 | 9.61 |
| ANXA2 | annexin A2 | 24.4 | ANKRD10 | Ankyrin repeat domain 10 | 9.59 |
| CAPN2 | calpain 2, (m/II) large subunit | 23.6 | AMT | aminomethyltransferase | 9.44 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 22.2 | PABPN1 | poly(A) binding protein, nuclear 1 | 9.36 |
| GALNT1 | UDP-N-acetyl-alpha-D- galactosamine:polypeptide N- acetylgalactosaminyltransferase 1 (GalNAc-T1) | 22.1 | APOE | apolipoprotein E | 9.30 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 21.4 | CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 9.28 |
| EFEMP2 | EGF-containing fibulin-like extracellular matrix protein 2 | 20.9 | CHD7 | chromodomain helicase DNA binding protein 7 | 9.10 |
| TRIB3 | tribbles homolog 3 (Drosophila) | 20.8 | FOXA3 | forkhead box A3 | 9.07 |
p < 1 × 10−2 for all genes