. 2012 Jul;191(3):1003–1013. doi: 10.1534/genetics.112.138909

Table 1 . QTL effects linked to simple sequence length polymorphisms (SSLP) for urinary calcium excretion residuals in a cohort of 236 F₂ genetic hypercalciuric stone-forming (GHS) × Wistar–Kyoto (WKY) rats at the 5% (α_0.05) and 10% (α_0.10) false discovery rate (FDR; Verhoeven et al. 2005).

Mbp (cM)			$μ_{W W} \pm 95 % C I$	$μ_{W G} \pm 95 % C I$	$μ_{G G} \pm 95 % C I$
Locus	Region	n	$σ_{W W}^{2}$ ( $C V_{W W}$ )	$σ_{W G}^{2}$ ( $C V_{W G}$ )	$σ_{G G}^{2}$ ( $C V_{G G}$ )	P	r²	Ar	P_cont
D1Rat95	66.8 (51)	160	0.75 ± 0.19	0.60 ± 0.16^a**	0.98 ± 0.19^a**	0.0018	5.73	UD	0.0031
	1p11		1.43 (52.1)	1.03 (48.8)	2.46 (61.3)
D1Mit2	135.0 (87)	236	0.78 ± 0.18	0.70 ± 0.12^a**	1.05 ± 0.17^a**	0.0026	4.06	D_W	0.0031
	1q31		1.17 (47.7)	1.18 (47.8)	2.79 (61.2)
D2Rat88	222.3 (69)	178	0.84 ± 0.21	1.08 ± 0.15^a**	0.67 ± 0.20^a**	0.0016	5.25	OD	0.0023
	2q42		1.38 (47.9)	2.69 (61.5)	1.07 (49.1)
D3Rat46	33.9 (34)	231	1.09 ± 0.18^a**	0.65 ± 0.12^a**	0.84 ± 0.17	<0.0001	6.03	UD	0.0007
	3q12		2.90 (63.8)	0.95 (43.8)	1.52 (53.4)
D4Mgh1	17.6 (8)	236	0.58 ± 0.16^a**	0.94 ± 0.12^a**	0.73 ± 0.19	0.0008	6.01	OD	0.0012
	4q12		0.75 (44.0)	2.16 (56.8)	0.96 (40.8)
D4Mit2	55.4 (36)	236	0.58 ± 0.17^a*	0.82 ± 0.12	0.92 ± 0.17^a*	0.0029	3.59	D_G	0.0073
	4q22		0.83 (51.6)	1.61 (52.5)	2.06 (46.9)
D4Rat76	84.9 (50)	231	0.55 ± 0.17^a^b*	0.79 ± 0.12^a*^c	1.01 ± 0.17^b**^c	0.0002	5.36	AD	0.0004
	4q24		0.89 (45.1)	1.44 (53.0)	2.24 (52.4)
D9Mgh2	84.4 (36)	197	0.86 ± 0.20	0.82 ± 0.14^a**	1.09 ± 0.22^a**	0.0079	2.21	D_W	0.0267
	9q35		1.46 (49.8)	1.97 (61.1)	2.11 (56.0)
D13Mit2	62.1 (24)	197	0.65 ± 0.18^a*	0.96 ± 0.14^a*	0.99 ± 0.23	0.0032	5.21	D_G	0.0024
	13q21		2.20 (44.2)	2.35 (61.1)	2.80 (56.9)
D14Rat22	102.5 (76)	236	0.78 ± 0.18	0.73 ± 0.12^a*	1.04 ± 0.18^a*	0.0013	3.25	D_W	0.0044
	14q22		2.39 (43.7)	2.30 (54.0)	2.53 (58.7)
D20Rat17	3.4 (0)	178	0.77 ± 0.20^a*	0.86 ± 0.15	1.16 ± 0.21^a*	0.0052	4.99	D_W	0.0022
	20q12		2.22 (49.8)	2.43 (50.9)	2.82 (67.9)

Genomic location within the chromosome is indicated in megabase pairs and in centimorgans on our F₂ GHS × WKY genomic map. Variance in untransformed urinary calcium excretion within genotypes ( $σ_{geno}^{2}$ ), coefficient of variation within genotypes (CV_geno), number of genotyped and phenotyped animals (n), adjusted P value (P_adj) from the ratio of the empirical P value against the 5% FDR threshold, correlational coefficient (r²) from linear statistical analysis, and variance within genotype (WW = WKY homozygote, WG = WKY/GHS heterozygote, GG = GHS homozygote) for PD_i in calcium excretion are given. Ar indicates the architecture (AD, additive; D_W, WKY dominant; D_G, GHS dominant; OD, overdominance; UD, underdominance) by SSLP locus and P_cont the significance of the contrast test associated with that architecture. All statistics were run in (SAS 2000). Means by genotype (µ) are given in milligrams per day. *, P < 0.05; **, P < 0.01; ***, P < 0.001.

Significant differences among genotypes for mean PD_i.

Table 1 . QTL effects linked to simple sequence length polymorphisms (SSLP) for urinary calcium excretion residuals in a cohort of 236 F2 genetic hypercalciuric stone-forming (GHS) × Wistar–Kyoto (WKY) rats at the 5% (α0.05) and 10% (α0.10) false discovery rate (FDR; Verhoeven et al. 2005).