| Ccr4/Pop2/Not complex |
Major mRNA deadenylaseCcr4 critical catalytic subunit, ExoIII family memberPop2: second catalytic subunit, RNaseD family memberNot1: large scaffolding proteinNot2–5, Caf130, Caf40: accessory proteins of unknown function |
Daugeron et al. (2001); Tucker et al. (2001, 2002); Chen et al. (2002)
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| Pan2/Pan3 complex |
Additional mRNA deadenylasePrimarily functions in initial trimming of poly(A) tailPan2: catalytic subunit; RNaseD family memberInteracts with and stimulated by Pab1Pan3: regulatory subunit |
Brown et al. (1996); Boeck et al. (1996); Brown and Sachs (1998)
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| Tpa1 |
Prolyl 4-hydroxylaseBinds poly(A)Interacts with eRF1 and eRF3Required for normal deadenylation and translation termination |
Keeling et al. (2006); Henri et al. (2010); Kim et al. (2010)
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| Pab1 |
Major poly(A)-binding proteinInhibits Ccr4 deadenylaseStimulates Pan2/Pan3 complexMay interact with eRF3 to affect deadenylationCouples deadenylation to decapping |
Caponigro and Parker (1995); Boeck et al. (1996); Cosson et al. (2002); Tucker et al. (2002); Hosada et al. (2003) |
| eRF3 (Sup35) |
Subunit of translation termination complex |
Hosada et al. (2003); Funakoshi et al. (2007)
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Interacts with Pab1 and thereby may influence deadenylation rates |
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| Rpb4/Rpb7 |
Two subunits of RNA polymerase II |
Lotan et al. (2005, 2007) |
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Required for normal rates of deadenylation |
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May exit from nucleus as part of mRNP to affect cytoplasmic deadenylation |
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