Table 5 . Twenty of the candidate genes with significant correlations between variation in transcript level and clearance ability at 4 weeks of age (in flies that were infected with E. coli).

FlyBase ID	Gene	BP	MF	Correlation	FDR P	Raw P
FBgn0032433	Organic anion transporting polypeptide 33Ea	Organic anion transport	Organic anion transmembrane transporter activity	0.94	0.001	0.00E+00
FBgn0027571	Fatty acid synthase	Metabolism	Fatty acid synthase activity	0.90	0.01	1.00E-05
FBgn0030114	CG17754	Phagocytosis, engulfment	—	0.87	0.02	7.00E-05
FBgn0035976	Peptidoglycan recognition protein LC	Immune response	Peptidoglycan binding	0.84	0.02	2.60E-04
FBgn0010379	RAC serine/threonine-protein kinase (Akt1)	Anti-apoptosis, insulin receptor signaling	Protein serine/threonine kinase activity	0.84	0.02	2.60E-04
FBgn0014020	Ras-like GTP-binding protein Rho1	Actin cytoskeleton organization, wound healing, etc	Protein/kinase binding	0.82	0.03	5.50E-04
FBgn0025595	Gonadotropin-releasing hormone receptor	Carbohydrate/lipid homeostasis	Peptide receptor activity	0.81	0.04	7.00E-04
FBgn0024326	MAP kinase kinase 4 (Mkk4)	Activation of JUN kinase	JUN kinase kinase activity	0.81	0.04	7.00E-04
FBgn0004364	18 wheeler	Immune response	Transmembrane receptor activity	0.80	0.04	8.60E-04
FBgn0261444	Tweety-2; CG3638	Phagocytosis, engulfment	—	0.80	0.04	8.60E-04
FBgn0002652	Squash	Gene silencing by RNA, oogenesis	—	−0.92	0.003	0.00E+00
FBgn0031739	CG14005	—	—	−0.86	0.02	1.00E-04
FBgn0004106	Cell division control protein 2 homolog	Response to DNA damage stimulus, asymmetric neuroblast division, etc.	Cyclin-dependent protein kinase activity, protein binding	−0.86	0.02	1.00E-04
FBgn0017418	Ariadne	Negative regulation of transcription	Specific transcriptional repressor activity, zinc ion binding	−0.85	0.02	1.90E-04
FBgn0013531	Mediator complex subunit 20	Regulation of transcription from RNA polymerase II promoter	Transcription coactivator activity	−0.82	0.03	5.50E-04
FBgn0040286	SC35; CG5442	Regulation of alternative nuclear mrna splicing, via spliceosome	Protein binding	−0.82	0.03	5.50E-04
FBgn0000579	Enolase	Glycolysis	Magnesium ion binding	−0.81	0.04	7.00E-04
FBgn0027903	DNA polymerase delta small subunit, CG12018	Response to DNA damage stimulus	DNA binding	−0.80	0.04	8.60E-04
FBgn0033773	mos; CG8767	Positive regulation of TOR signaling cascade	Protein kinase activity	−0.80	0.045	1.07E-03
FBgn0029712	CG15912	Metabolism	Phosphoglycolate phosphatase activity	−0.80	0.05	1.13E-03

Positively correlated genes are at the top of the table and negatively correlated genes are at the bottom of the table. Positive correlations indicate that a higher expression level is associated with higher infection levels (poorer clearance) and negative correlations indicate that a higher expression level is associated with a lower infection level (better clearance). The complete list of candidate genes can be found in Table S3 (for the flies that were wounded only) and Table S4 (for the flies that were infected with E. coli).