Table 2.
Factors associated with estrogen receptor status among breast cancer cases (event = ER negative)
| Risk factors | Hispanics | Non-Hispanics | ||||||
|---|---|---|---|---|---|---|---|---|
| ER+N (%) | ER−N (%) | Age adjusted OR |
Fully adjusted OR (95% CI)a |
ER+N (%) | ER−N (%) | Age adjusted OR |
Fully adjusted OR (95% CI)a |
|
| Women <50 years | ||||||||
| BMI (kg/m2) | ||||||||
| <25 | 58 (57) | 43 (43) | Ref | Ref | 167 (82) | 36 (18) | Ref | Ref |
| 25–29.9 | 49 (58) | 36 (42) | 1.11 | 0.88 (0.44, 1.74) | 63 (65) | 34 (35) | 2.93 | 2.70 (1.32, 5.51) |
| ≥30 | 54 (77) | 16 (23) | 0.41 | 0.29 (0.13, 0.66) | 44 (68) | 21 (32) | 2.58 | 2.47 (1.08, 5.67) |
| P. activity | ||||||||
| Sedentary | 46 (60) | 31 (40) | Ref | Ref | 85 (73) | 31 (27) | Ref | Ref |
| Moderate | 52 (66) | 27 (34) | 0.80 | 0.53 (0.24, 1.16) | 101 (78) | 28 (22) | 0.67 | 0.61 (0.30, 1.25) |
| Vigorous | 63 (63) | 37 (37) | 0.98 | 0.55 (0.27, 1.13) | 88 (73) | 32 (27) | 0.72 | 0.63 (0.32, 1.60) |
| Alcohol (gm/day) | ||||||||
| None | 97 (64) | 55 (36) | Ref | Ref | 136 (75) | 46 (25) | Ref | Ref |
| Moderate (>0–3.49) | 33 (69) | 15 (31) | 0.80 | 0.84 (0.38, 1.87) | 40 (71) | 16 (29) | 1.18 | 1.60 (0.68, 3.76) |
| High (≥3.49) | 31 (55) | 25 (45) | 1.42 | 1.26 (0.59, 2.71) | 98 (77) | 29 (23) | 0.87 | 0.75 (0.35, 1.63) |
| Age, first pregnancy (years) | ||||||||
| <20 | 33 (59) | 23 (41) | Ref | Ref | 24 (59) | 17 (41) | Ref | Ref |
| 20–24 | 50 (57) | 38 (43) | 1.05 | 1.02 (0.47, 2.21) | 56 (72) | 22 (28) | 0.54 | 0.54 (0.22, 1.34) |
| ≥25 | 59 (71) | 24 (29) | 0.62 | 0.51 (0.21, 1.24) | 129 (82) | 28 (18) | 0.30 | 0.25 (0.09, 0.65) |
| Time since last pregnancy (years) | ||||||||
| <15 | 94 (62) | 58 (38) | Ref | Ref | 132 (73) | 48 (27) | Ref | Ref |
| ≥15 | 53 (63) | 31 (37) | 1.56 | 1.004 (0.50, 2.0) | 98 (77) | 29 (23) | 0.81 | 0.46 (0.22, 0.94) |
| Women ≥50 years | ||||||||
| BMI (kg/m2) | ||||||||
| <25 | 62 (79) | 16 (21) | Ref | Ref | 231 (83) | 47 (17) | Ref | Ref |
| 25–29.9 | 80 (78) | 23 (22) | 1.11 | 1.32 (0.59, 2.94) | 170 (82) | 37 (18) | 1.10 | 1.06 (0.63, 1.79) |
| ≥30 | 90 (84) | 17 (16) | 0.73 | 0.68 (0.29, 1.60) | 166 (80) | 41 (20) | 1.23 | 1.36 (0.80, 2.31) |
| P. activity | ||||||||
| Sedentary | 85 (83) | 18 (17) | Ref | Ref | 212 (80) | 54 (20) | Ref | Ref |
| Moderate | 67 (80) | 17 (20) | 1.20 | 1.09 (0.49, 2.39) | 184 (85) | 32 (15) | 0.69 | 0.69 (0.41, 1.15) |
| Vigorous | 82 (80) | 21 (20) | 1.21 | 1.21 (0.55, 2.65) | 174 (82) | 39 (18) | 0.91 | 0.98 (0.59, 1.61) |
| Alcohol (gm/day) | ||||||||
| None | 164 (80) | 40 (20) | Ref | Ref | 312 (80) | 77 (20) | Ref | Ref |
| Moderate (>0–3.49) | 32 (80) | 8 (20) | 1.02 | 0.71 (0.24, 2.08) | 96 (82) | 21 (18) | 0.87 | 0.85 (0.47, 1.54) |
| High (≥3.49) | 38 (83) | 8 (17) | 0.86 | 0.77 (0.30, 1.94) | 162 (86) | 27 (14) | 0.67 | 0.61 (0.35, 1.06) |
| Age, first pregnancy (years) | ||||||||
| <20 | 51 (76) | 16 (24) | Ref | Ref | 85 (81) | 20 (19) | Ref | Ref |
| 20–24 | 97 (80) | 24 (20) | 0.79 | 0.80 (0.37, 1.76) | 236 (83) | 50 (17) | 0.92 | 0.87 (0.48, 1.56) |
| ≥25 | 58 (82) | 13 (18) | 0.71 | 0.86 (0.34, 2.16) | 167 (79) | 45 (21) | 1.12 | 1.13 (0.61, 2.11) |
| Time since last pregnancy (years) | ||||||||
| <15 | 13 (76) | 4 (24) | Ref | Ref | 16 (76) | 5 (24) | Ref | Ref |
| ≥15 | 198 (80) | 50 (20) | 0.78 | 0.74 (0.21, 2.65) | 495 (82) | 111 (18) | 0.72 | 0.79 (0.27, 2.35) |
| HRTb | ||||||||
| Ever | 132 (84) | 26 (16) | Ref | Ref | 418 (81) | 96 (19) | Ref | Ref |
| Never | 96 (77) | 29 (23) | 1.54 | 1.62 (0.85, 3.11) | 137 (85) | 25 (15) | 0.79 | 0.80 (0.46, 1.38) |
BMI and HRT are not adjusted for each other, but adjusted for all other variables
a
Adjusted for all the variables listed in the table in addition to parity, mammography use, family history of breast cancer, and smoking
b
Postmenopausal women only
Bold values indicate P < 0.05