Skip to main content
. Author manuscript; available in PMC: 2013 Jun 28.
Published in final edited form as: J Control Release. 2012 Apr 10;160(3):561–569. doi: 10.1016/j.jconrel.2012.04.005

Figure 6. Positive gene expression from pDNA delivered as a liquid formulation via microneedles to viable human skin.

Figure 6

(A) En face image showing positive points of gene expression resulting from multiple applications of the microneedle device through a pre-applied solution of plasmid encoding β-galactosidase and 24 hrs in organ culture (bar = 1mm). (B) A human epidermal sheet treated with a microneedles and a liquid formulation of plasmid encoding EGFP (bar = 50μm). (C) 10μm histological section showing positive gene confined to the epidermis (bar = 100μm).

HHS Vulnerability Disclosure