Figure 7. Positive gene expression from microneedle-coated pDNA delivered to viable human skin.
(A) En face image of a single point of gene expression from a plasmid encoding β-galactosidase with the microneedle device as a scale reference. (B) A H&E stained 10 μm histological section of human skin showing the point of microneedle penetration and the positive gene expression from the delivered dry coated plasmid encoding β-galactosidase (bar = 100μm). (C) Human epidermal sheet treated with a microneedle device dry-coated with a plasmid encoding EGFP (bar = 100μm).