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. Author manuscript; available in PMC: 2012 Sep 30.
Published in final edited form as: Cell. 2011 Sep 30;147(1):235–246. doi: 10.1016/j.cell.2011.08.040

Figure 1. Cntnap2−/− mice show epileptic seizures and abnormal EEG pattern.

Figure 1

(A) Presence of reactive astrocytes in the hipocampal hilus (inset) of P180 but not P14 mutant mice without significant changes in neuronal density. GFAP, glial fibrillary acidic protein; NeuN, neuronal nuclei. Scale bar: 50 µm. GFAP quantification is shown as % of area occupied by reactive astrocytes. n=4 mice/genotype for each age. Data are presented as mean ± S.E.M. ***p<0.001 (B) EEG recording from mutant mice show abnormal spike discharges (arrows) after seizure onset. n=3 mice for each age. RF, right frontal; RP, right parietal. See also Table S1, Movie S1 and Figure S3C.