Table 1. Licensed indications, mechanism of action and comparative tolerability and side effects of SSRIs.[77].

	FDA approved year	FDA therapeuticindications	Mechanism of action	Cardiovascular profile
Citalopram	1998	Major depressive disorder	A highly selective and potent serotonin reuptake inhibitor	Uncommon (≥ 1/1000 to <1/100): bradycardia, orthostatic hypotension, tachycardia; Rare (≥ 1/10000 to <1/1000): atrial fibrillation, bundle branch block, cardiac arrest, hypertension, myocardial infarction, phlebitis, transient ischemic attacks, stroke
Escitalopram	2002	Major depressive disorder; generalized anxiety disorder	More selective serotonin reuptake inhibitor than citalopram	Uncommon (≥ 1/1000 to <1/100): tachycardia;Rare (≥ 1/10000 to <1/1000): bradicardia, orthostatic hypotension
Fluoxetine	1987	Bulimia nervosa; major depressive disorder; obsessive compulsive disorder; panic disorder; premestrual dysphoric disorder	Potent and selective inhibitor of serotonin reuptake with antidepressant, antiobsessional and antibulimic effects	Uncommon (≥ 1/1000 to <1/100): junctional rhytms, mild bradycardia, sinus tachycardia, ventricular trigeminy; Rare (≥ 1/10000 to <1/1000): ECG abnormalities, thrombophlebitis
Fluvoxamine	1993	Major depressive disorder; obsessive compulsive disorder	A selective serotonin reuptake inhibitor with affinity for the serotonin transporter over the norepinephrine transporter	Uncommon (≥ 1/1000 to <1/100): ST segment changes, atrioventricular and supraventricular blockade; Rare (≥ 1/10000 to <1/1000): coronary heart disease, embolus, pericarditis, phlebitis, pulmonaty infarction, stroke
Paroxetine	1992	Generalized anxiety disorder; major depressive disorder; obsessive compulsive disorder; panic disorder; post-traumatic stress disorder; premestrual dysphoric disorder; social anxiety disorder	The most potent inhibitor of the reuptake of serotonin	Uncommon (≥ 1/1000 to <1/100): hypertension, syncope, tachycardia; Rare (≥ 1/10000 to <1/1000): angina pectoris, bradycardia, congestive heart failure, hypotension, myocardial infarction, thrombophlebitis, vascular headache
Sertraline	1991	Major depressive disorder; obsessive compulsive disorder; panic disorder; post-traumatic stress disorder; premestrual dysphoric disorder; social phobia	Selective inhibitor of the reuptake of serotonin and a weak activity in inhibiting the reuptake of dopamine	Uncommon (≥ 1/1000 to <1/100): hypertension, postural hypoternsion, tachycardia;Rare (≥ 1/10000 to <1/1000): angina pectoris, bradycardia, myocardial infarction, stroke

SSRIs: Selective serotonin reuptake inhibitors; FDA: Food and Drug Administration; ECG: Electrocardiogram.