Table 1.

Previously reported association results with ADAM33 gene polymorphisms with asthma and BHR

#The SNP designations are derived from the exon labeling (see Fig. 2).

Association with Asthma (+); BHR (B); SNPs that are not significantly associated (−); SNPs not studied (*).

§In case–control studies number of cases and controls and in family studies number of families and individuals.

¶Two hundred sixty-five Mexican families and 318 Puerto Rican families, no association in single or in pooled populations.

‖In the study of Raby et al., eight additional SNPs were investigated: G1, I1, KL + 3, N1, S + 1, T + 2, V-2, and V3. None of the additional SNPs showed an association with asthma.

##Only trend (0.05 < p ≤ 0.06).

§§In the study of Kedda et al., three additional SNPs were investigated: V-2, V2, and V5.

¶¶Haplotype of ADAM33 SNPs showed association with asthma.

BHR = bronchial hyperresponsiveness; cc = case control; fa = family study; n = number; SNP = single nucleotide polymorphism.