Table 1.
Summary of effects of green tea polyphenols on skin.
| GTPP protective effect | Cellular and/molecular response | References |
|---|---|---|
| UV protection | Inhibits UVB-induced MAPK activation and phosphorylation of ERK1/2, JNK and p38. | [51–54, 57] |
| Attenuates nuclear transcription factors, c-Jun p53, and c-fos | ||
|
| ||
| Antioxidant | Free radical scavenging activity | [35, 48, 53, 54, 56, 57] |
| Inhibits NOS, H2O2 production | ||
| Prevents UVB-induced depletion of antioxidant enzymes: catalase, glutathione peroxidase, superoxide dismutase, and glutathione | ||
| Inhibits UVB-induced LPO and protein oxidation | ||
|
| ||
| Anti-inflammation | Prevents UV-induced depletion of CD1a + LC and APC Inhibits UV-induced infiltration of monocytes, macrophages, neutrophils | [37, 45, 55, 57, 60] |
| Protects UVB-induced immunosuppression via IL-12 production | ||
| ↓ in histamine release by mast cells | ||
|
| ||
| Anticarcinogenesis | Inhibits DNA damage. | [45, 48, 59, 60] |
| Inhibits UV-induced CPD, 8-OHdG formation | ||
| DNA repair enzyme activation | ||
| Modulates transcriptions factors AP1, NFKB | ||
| Inhibits tumor growth, progression and angiogenesis | ||
LC: langerhans cells; LPO: lipid peroxidase; MAPK: mitogen-activated protein kinase; NOS: nitric oxide synthase.