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Alterations in the Eph/ephrin system cause a delayed migration of cortical interneurons in vivo. Analysing the calbindin-(CB-) positive interneurons in the cortex of E14.5 embryos revealed a delayed migration of interneurons in hetero- and homozygotic ephrin-B3/EphA4 knockout mice compared to the wild-type (WT) littermates. Arrow heads indicate the front of migrating interneurons. Scale bar: 100 μm.
