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. Author manuscript; available in PMC: 2013 Jun 26.
Published in final edited form as: Biochemistry. 2012 Jun 13;51(25):5212–5222. doi: 10.1021/bi300476v

Table 2.

Gefitinib concentration for relative IC50 inhibition of WT and L834R EGFR autophosphorylation at individual tyrosine residues.

tyrosine residue wild type (μM) L834R (μM) a fold difference a
845 13.12 ± 3.51 0.54 ± 0.24 24.3
992 10.21 ± 2.52 0.26 ± 0.10 39.3
1045 5.46 ± 0.40 0.1 50
1068 28.87 ± 6.29 3.29 ± 1.08 8.8
1148 33.34 ± 4.72 4.94 ± 1.58 6.7
1173 32.11 ± 6.67 3.64 ± 1.38 8.8
a

Gefitinib concentrations for relative IC50 inhibition of L834R EGFR autophosphorylation indicate upper limit.

b

Fold differences indicate lower limit.