Table 2.
tyrosine residue | wild type (μM) | L834R (μM) a | fold difference a |
---|---|---|---|
845 | 13.12 ± 3.51 | 0.54 ± 0.24 | 24.3 |
992 | 10.21 ± 2.52 | 0.26 ± 0.10 | 39.3 |
1045 | 5.46 ± 0.40 | 0.1 | 50 |
1068 | 28.87 ± 6.29 | 3.29 ± 1.08 | 8.8 |
1148 | 33.34 ± 4.72 | 4.94 ± 1.58 | 6.7 |
1173 | 32.11 ± 6.67 | 3.64 ± 1.38 | 8.8 |
Gefitinib concentrations for relative IC50 inhibition of L834R EGFR autophosphorylation indicate upper limit.
Fold differences indicate lower limit.