Figure 8.
Potency of activation of αtwiβδγ receptors by ACh, choline, and curare. A, Recording of macroscopic current in oocytes expressing αtwiβδγ and held at −50 mV. Addition of either 10 μm curare, 1 mm choline, or 300 nm ACh effectively evoked an inward current. B, Overall comparisons of activation by choline (black) and curare (gray) on each of the different receptor isoforms. The bar graph reflects the mean fractional activation ± SD of peak ACh-activated current associated with either curare or choline treatment and the number of oocytes tested is indicated.