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. Author manuscript; available in PMC: 2012 Jul 5.
Published in final edited form as: Free Radic Biol Med. 2011 Apr 14;51(1):30–37. doi: 10.1016/j.freeradbiomed.2011.04.016

Fig. 5. MnTE enhances long-term and multi-lineage engraftment of irradiated HSCs after BM transplantation.

Fig. 5

Donor cell engraftment was determined at 1 and 2 months in lethally irradiated recipients after transplantation of BM-MNCs from control or TBI mice treated with vehicle or MnTE as described above in a competitive repopulating assay. The percentage of donor-derived peripheral blood leukocytes (CD45.2+ cells) (A), T cells (CD45.2+Thy-1.2+ cells) (B), B cells (CD45.2+B220+ cells) (C), and myeloid (CD45.2+CD11b+ and/or Gr-1+ granulocyte-monocyte-macrophage) (D) are presented as mean ± SE (5–6 mice/group). a, p<0.05 vs. control; and b, p<0.05 vs. TBI with vehicle. E & F. Representative analyses of donor cell engraftment by flow cytometry. Upper panel: total donor (CD45.2+) cell engraftment; Lower panel: engraftment of donor-derived T (CD45.2+Thy-1.2+ cells), B (CD45.2+B220+ cells), and M (myeloid, CD45.2+CD11b+ and/or Gr-1+) cells.