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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: Bioorg Med Chem. 2012 May 19;20(14):4443–4450. doi: 10.1016/j.bmc.2012.05.026

Scheme 1.

Scheme 1

Reagents and conditions: (a) 1.0 equiv. 2, 1.0 equiv. NaN3, DMF, 18 h, 90 °C, 82%; (b) 0.05 equiv. Pd/C, methanol, 18 h, 25 °C, 95%; (c) 1.0 equiv. 4, 2.0 equiv. Boc2O, 2.0 equiv. Et3N, methanol, 18 h, reflux, 90%; (d) 1.0 equiv. 5, 1.0 equiv. 6, 1.1 equiv. EDC, 1.1 equiv. HOBT, CH2Cl2, 18 h, 25 °C, 78%.