Skip to main content
. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: Bioorg Med Chem. 2012 May 19;20(14):4443–4450. doi: 10.1016/j.bmc.2012.05.026

Scheme 2.

Scheme 2

Reagents and conditions: (a) 1.0 equiv. 7, 1.5 equiv. 8, 0.1 equiv. DBU, 18 h, 25 °C, 62%; (b) 1.0 equiv. 9, TFA/CH2Cl2, 30 min, 25 °C; (c) 1.0 equiv. 11, 1.1 equiv. 10, 2.0 equiv. DIPEA, 0.1 equiv. DMAP, CH2Cl2, 18 h, 25 °C, 83% (over two steps).