TABLE 1.

Low-risk human papillomavirus subtypes versus high-risk human papillomavirus subtypes

	LOW RISK: HUMAN PAPILLOMAVIRUS SUBTYPES 6 AND 11	HIGH RISK: HUMAN PAPILLOMAVIRUS SUBTYPES 16 AND 18
Main pathologic association	75-90% cases of genital warts	70% cases of all invasive cervix cancer
Pathogenesis	Remain separate from host cell DNA, undergo independent replication	Integrate viral DNA with host's genome promoting transcription of oncoproteins that inactivate tumor suppressor genes
Associated with which types of verrucous carcinoma	Oral florid papillomatosis Buschke-Lowenstein tumor	Oral florid papillomatosis
Vaccination	HPV4	HPV2 HPV4

HPV 4: Gardasil (Merck & Co.), HPV2: Cervarix, (GlaxoSmithKline)