Table 1.

Cell viability data of ethyl acetamide side chain novologues.

Entry	R1	R2	R3	X	Y	% of cell viabilitya
2	-	-	-	-	-	86% ± 2
13a	H	H	H	C	C	76%±11#
13b	H	F	H	C	C	95%±14#
13c	H	H	F	C	C	75%±27#
13d	Cl	H	H	C	C	71%±21#,*
13e	H	Cl	H	C	C	90%±23#
13f	H	CF3	H	C	C	83%±16#
13g	H	H	CF3	C	C	74%±19#,*
13h	SMe	H	H	C	C	83%±4O#
13i	OMe	H	H	C	C	92%±10#
13j	H	OMe	H	C	C	78%±34#
13k	H	Me	H	C	C	82%±30#
13l	H	CH2-N-morpholine	H	C	C	83%±26#
13m	H	H	OH	C	C	67%±10*
13n	H	-OCH2O-		C	C	83%±18#
13o	H	H	H	N	C	61%±7*
13p	H	H	H	C	N	81%±12#

^aIn the presence of 1 μM of each novologue + 20 mM excess glucose. Viability in the presence of 20mM excess glucose + DMSO was 54% ± 2.

^#p<0.05 versus glucose + DMSO;

^*p<0.05 versus glucose + compound 2 (n=6–24) per novologue.