Table 2.
Top Canonical Pathways identified through Ingenuity Pathway Analysis
| Ingenuity Canonical Pathway | p-value | Significant Metabolites |
|---|---|---|
| Alanine and Aspartate Metabolism | 1.25E-06 | L-alanine, pyruvic acid, L-malic acid, L-aspartic acid, 2-oxoglutaric acid, succinic acid |
| Glyoxylate and Dicarboxylate Metabolism | 1.03E-04 | pyruvic acid, L-malic acid, formic acid, 2-oxoglutaric acid, succinic acid |
| Phenylalanine Metabolism | 2.1E-04 | pyruvic acid, L-phenylalanine, benzoic acid, succinic acid |
| Citrate Cycle | 2.57E-04 | pyruvic acid, L-malic acid, 2-oxoglutaric acid, succinic acid |
| Aminoacyl-tRNA Biosynthesis | 3.92E-04 | L-alanine, L-isoleucine, L-leucine, L-phenylalanine, L-aspartic acid |
| Butanoate Metabolism | 5.19E-04 | pyruvic acid, 2-oxoglutaric acid, butyric acid, succinic acid |
| Valine, Leucine and Isoleucine Biosynthesis | 7.35E-04 | L-isoleucine, L-leucine, pyruvic acid |
| Glutamate Metabolism | 8.14E-04 | glutathione, L-malic acid, 2-oxoglutaric acid, succinic acid |
| Pyruvate Metabolism | 0.0035 | pyruvic acid, L-malic acid, formic acid |
| Cysteine Metabolism | 0.0035 | L-alanine, glutathione, pyruvic acid |
| Histidine Metabolism | 0.00527 | L-aspartic acid, 2-oxoglutaric acid,3-methylhistidine |
| Nitrogen Metabolism | 0.0075 | L-phenylalanine, formic acid, L-aspartic acid |
| Arginine and Proline Metabolism | 0.0509 | pyruvic acid, L-aspartic acid, adenine |
Fisher’s exact test was used to calculate a p-value determining the probability that the association between the genes in the dataset and the canonical pathway is explained by chance alone.