Figure 7.
Inhibition of N-glycosylation of NKCC1 normalizes GABA inhibition and the EGABA of PVN presympathetic neurons in hypertension. a, b, Changes in GABA currents recorded at different holding potentials (a) and the EGABA (b) of labeled PVN neurons in SHR brain slices treated with vehicle (n = 7 neurons), tunicamycin (n = 7 neurons), or tunicamycin plus bumetanide (n = 6 neurons). c, d, Original recordings (c) and mean changes in the membrane potential (d) induced by puff GABA application to labeled PVN neurons of SHRs. TM, Tunicamycin. ***p < 0.001, compared with the vehicle-treated group.