Table 2. Survival of F98 glioma-bearing rats after carboplatin chemotherapy.

Carboplatin was delivered by CED on day 13 after tumor inoculation for groups 2, 3 and 4; and on day 8 for group 5. A survival time of 200 days was considered as the endpoint of the study. Rats still alive at 200 days after inoculation of 10³ F98 glioma cells were euthanized.

Group	N*	Carboplatin CED treatment (dose/volume)	Survival time (days)			% Increased life span
			Range	Mean ± SE‡	Median	Mean	Median
1	7	Untreated	22–34	29 ± 2	30	-	-
2	10	20 μg/20 μl	32–120	55 ± 8	45	90	63
3	7	40 μg/40 μl	16–59	37 ± 6	32	26	7
4	6	100 μg/20 μl	16–52	29 ± 5	26	0	−13
5	8	40 μg/40 μl (at day 8)	27–200§	64 ± 22 (biased)	33	120 (biased)	10

^*N is the number of animals per group.

^§One rat was still alive at day 200.

^‡SE is the standard error of the mean.