Figure 4. Histological scoring confirms the accelerated recovery of Hsp72 mice from caerulein - induced pancreatitis.

(A–C) Animals subjected to caerulein for 6, 12, 36 and 96 hours as well as untreated animals were histologically evaluated with respect to their tissue edema (A), extent of necrosis (B) as well as leucocyte infiltration (C). Note that 36 hours after caerulein-injection, Hsp72 mice (black bars) display significantly lower values in all three assessed parameters than their non-transgenic littermates (grey bars). D) Serum lipase levels were measured in Hsp72 (black bars) and nontransgenic (grey bars) mice and visualized as mean ± SEM values from at least 4 mice per group/time point. Note that 36 hours after caerulein injection, Hsp72 mice display significantly lower lipase levels than the nontransgenic animals. *P< 0.05.