Figure 8. Hsp72 overexpression does not protect from L-arginine-induced acute pancreatitis.

(A) Pancreatic tissue sections from nontransgenic (a, c) and Hsp72 mice (b, d) were stained with haematoxylin and eosin prior to (a,b) and after treatment with L-arginine (c, d). Scale bars (a–d), 100 µm. (B) Morphometric analysis of histological sections reveals the extent of edema, necrosis and leukocyte infiltration in nontransgenic (grey bars) and Hsp72 animals (black bars) injected with L-arginine (C) Serum lipase levels and pancreatic water content (D) determine the extent of pancreatic/acinar injury in Hsp72 (black bars) and nontransgenic mice (grey bars) subjected to L-arginine. The data are presented as mean ± SEM. At least 5 mice were used per group/time point.