Skip to main content
. 2012 Jul 5;7(7):e40124. doi: 10.1371/journal.pone.0040124

Figure 1. Estrogen induced premature catagen and suppressed HFs at telogen in a reversible manner.

Figure 1

(A) Estrogen administration inhibited hair regrowth. At the tenth day after hair shaving (P64), the estrogen treated mice remained bald, whereas the backs of the vehicle oil treated mice were fully covered by hairs. (B) Estrogen induced premature catagen and arrested HFs at telogen. After orchidectomy, HFs entered a long-lasting anagen (P30–49). In contrast, just after four days of 17β-estradiol injection (P44), the hairs were obliged to enter catagen from anagen, and stayed at telogen until at least ten days after stopping injection (P54–64). However, 15 days after withdrawal of the 17β-estradiol treatment (P69), the mice had their hairs regrown. The period of 17β-estradiol or vehicle oil treatment is highlighted by blue. E2: 17β-estradiol; HF: hair follicle. Scale bar: 100 µm.