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. 2012 Jul 5;7(7):e39973. doi: 10.1371/journal.pone.0039973

Table 2. Protective capacity of 8 M urea-denatured, recombinant PlpE in chickens and mice.

Species	Experiment^a	Immunogen	Challenge		Survival^b	P value^c
			Strain	Dose (CFU)	No. surviving/total
chicken	2	adjuvant control	X73	10³	0/7
		killed X-73 control		10³	7/7	<0.001
		PlpE		10³	7/7	<0.001
chicken	3	adjuvant control	VP161	300	0/10
		killed Vp161 control		300	7/10	<0.001
		killed X73 control		300	3/10
		PlpE		300	5/10	0.03
mouse	1	adjuvant control	X73	34	0/10
		killed X73 control		60	5/5	<0.001
		PlpE		34	7/10	0.003
mouse	2	adjuvant control	X73	44	0/10
		PlpE		44	7/9	<0.001

^a

Results of chicken experiment 1 are shown in Table 1.

^b

All animals deemed incapable of survival were euthanized in accordance with animal ethics requirements.

^c

Compared to adjuvant control: Fisher’s exact test.