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. 2012 Jul 5;8(7):e1002806. doi: 10.1371/journal.pgen.1002806

Figure 4. Endogenous TDP-1 protein levels influenced by stress and Insulin/IGF signaling.

Figure 4

Western blotting of worm extracts from different strains under normal and stress conditions with an anti-TDP-1 antibody. (A) Osmotic and oxidative stress significantly increased the expression of TDP-1 in N2 worms. (B) The level of TDP-1 protein was comparable in untreated and osmotically stressed daf-2(e1370) worms. TDP-1 protein expression was significantly increased by exposure to oxidative stress in daf-2(e1370) worms. (C) TDP-1 protein levels remained low in daf-2(e1368) animals with or without stress. (D) TDP-1 protein expression was significantly increased by osmotic stress in daf-16(mu86) animals. Oxidative stress did not induce TDP-1 expression in daf-16 mutants.