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. 2012 Jul 5;8(7):e1002806. doi: 10.1371/journal.pgen.1002806

Figure 8. Opposing effects of daf-2 on proteotoxicity.

Figure 8

(A) daf-2(e1368);TDP-43[A315T] animals had significantly deceased rates of paralysis, while daf-2(e1370);TDP-43[A315T] animals had enhanced paralysis compared to TDP-43[A315T] transgenics alone (P<0.001). (B) daf-2(e1368);TDP-43[A315T] animals had significantly deceased motor neuron degeneration, while daf-2(e1370);TDP-43[A315T] animals had enhanced neurodegeneration compared to TDP-43[A315T] transgenics alone (*P<0.001, **P<0.05). (C) Western blotting revealed a significant reduction in the amount of insoluble TDP-43 protein in extracts from daf-2(e1368);TDP-43[A315T] animals compared to TDP-43 alone. daf-2(e1370) had no effect on mutant TDP-43 solubility. Please also see Table S3.