Figure 8. Inhibition of hilar GABAergic interneuron activity did not alter non-hippocampus-dependent behavior.
(A, B) I12b-Cre mice injected with AAV1-DIO-eNpHR3.0-eYFP virus were tested for short-term working memory with (On) or without (Off) laser illumination in a Y maze test. Data were reported as total movement (A) and % alternation (B). Values are mean ± SEM. (C) I12b-Cre mice injected with AAV1-DIO-eNpHR3.0-eYFP virus were tested for motor coordination with (On) or without (Off) laser illumination in a rotarod test. Values are mean ± SEM. (D, E) I12b-Cre mice injected with AAV1-DIO-eNpHR3.0-eYFP virus were tested for exploratory activity with (On) or without (Off) laser illumination in a open field test. Data were reported as the number of total activities (D) and the ratio of central activity to total activity (E). Values are mean ± SEM. n = 8–10 mice/group.