Figure 2. Enzyme turnover rates show higher correlation with average flux across media and with flux under aerobic conditions.

(A) Histogram of Pearson correlations between enzyme turnover numbers and predicted flux rates under different single carbon and energy source media (in blue). The Pearson correlation between enzyme turnover numbers and the averaged flux distribution across conditions (in green) is shown to be markedly higher than those obtained under the different media. (B) Pearson correlations between enzyme turnover numbers and predicted fluxes under a set of single carbon and energy source media under either aerobic versus anaerobic conditions. As shown, under most growth conditions, the correlation between enzyme turnover numbers and fluxes is higher when fluxes are predicted under aerobic conditions.