Skip to main content
. 2012 Jul 5;8(7):e1002787. doi: 10.1371/journal.ppat.1002787

Table 1. Cytolytic activity of PFO derivatives with mutations in the Arg-468 residue.

Toxin EC50 (M) % WT
PFO 6.0×10−11 100
R468A 6.0×10−9 1
R468K 5.0×10−9 1
R468Q 2.4×10−8 <1
R468E 3.9×10−8 <1

Cytolytic activity of PFO and Arg-468 mutants is shown as the effective concentration (EC50) of toxin required for 50% lysis of human erythrocytes under standard assay conditions (see Materials and Methods for details).