Figure 8. WP1130 inhibits MNV-1 infection in mice.

Balb/c mice were administered 30 mg/kg of WP1130 dissolved in 20% DMSO and 80% PEG200 or vehicle control once daily via oral gavage. Mice were infected orally with 1×10⁶ PFUs of MNV-1 four hours after the first dose of WP1130. After 72 hours of infection, tissues were harvested along the gastrointestinal tract and viral titers determined by plaque assay. Shown are viral titers in the jejunum/duodenum of mice treated with WP1130 (empty box) or vehicle control (filled circle). Each symbol represents one animal. Data are from three independent experiments and are presented as means +/− S.E.M. **P<0.01.