Table 1.
Summary of select outcomes from the Management of Myelomeningocele Study randomized controlled trial.
| Prenatal Surgery (N = 78) |
Postnatal Surgery (N = 80) |
Relative Risk (95% CI) |
P Value | |
|---|---|---|---|---|
| Primary outcomes | ||||
| Primary outcome at 12 months1 | 53 (68%) | 78 (98%) | 0.70 (0.58–0.84) | <0.001 |
| Primary outcome at 30 months2 | 148.6 ± 57.5 (SD) | 122.6 ± 57.2 (SD) | - | 0.007 |
| Secondary outcomes | ||||
| Hindbrain herniation (12 months) | 45/70 (64%) | 66/69 (96%) | 0.67 (0.56–0.81) | <0.001 |
| Shunt placement (12 months) | 31 (40%) | 66 (82%) | 0.48 (0.36–0.64) | <0.001 |
| Walking independently (30 months) | 26/62 (42%) | 14/67 (21%) | 2.01 (1.16–3.48) | 0.01 |
1
Based on incidence of fetal or neonatal death or need for shunt placement by 12 months.
2
Composite score based on Bayley Mental Developmental Index and the difference between observed and expected motor function at age 30 months. Higher values indicate better function.