Fig. 2.

Periductal infiltration of lymphocytes in the labial salivary glands (LSGs) from two representative Sjögren's syndrome (SS) patients. Each set of serial sections was stained with haematoxylin and eosin (H&E) (a,f), anti-CD3 (b,g), anti-CD19 (c,h), anti-CD4 (d,i) and anti-CD8 (e,j) monoclonal antibodies, as described in the Patients and methods section. The degrees of lymphocytic infiltration in the LSGs from the two patients had focus scores 3 and 12. There was a predominance of CD3⁺ and CD8⁺ T cells compared with CD19⁺ B cells and CD4⁺ T cells, respectively, with focus score 3 LSGs (a–e). However, there was a predominance of CD19⁺ B cells and CD4⁺ T cells compared with CD3⁺ T cells and CD8⁺ T cells, respectively, with focus score 12 LSGs (f–j) (original magnification ×100).