Fig. 1.

Both soluble tumour necrosis factor receptor-immunoglobulin (sTNFR-Ig) and XPro1595 can inhibit sTNF production but only sTNFR-Ig can suppress interleukin (IL)-6 secretion. Bone marrow-derived macrophages (BMDMϕ) from wild-type mice were incubated with 100 ng/ml lipopolysaccharide (LPS) for 24 h in the presence of 10 µg/ml human IgG or sTNFR-Ig (a,c) or 10 µg/ml I-XPro or XPro1595 (b,d). TNF (a,b) or IL-6 (c,d) production was quantified by enzyme-linked immunosorbent assay. Mean ± standard error shown, n = 3, *P < 0·05.