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Role of HU and ISC1 deletion on the survival of mice and on lung tissue burden. (A) Survival curve of CBA/J mice upon infection with WT Cn in the presence (green) or absence (black) of HU; (B) Survival curve of CBA/J mice upon infection with Cn isc1Δ cells in the presence (red) or absence (blue) of HU. (C) Survival of Cn cells in lung tissue of CBA/J mice after 60 days of infection. Lung t-issues were collected from mice and Cn CFU was counted by plating on YPD plates.
