Table 3. Enriched Blood Culture Results.
| Group | Route of Challenge | Target dose (cfu/mouse) | Blood Culture Collection | Number of animals positive/Total number of animals in group |
|---|---|---|---|---|
| 6 | Aerosol | 1.00E+04 | Day 14 | 0/11 |
| 7 | Aerosol | 1.00E+04 | Day 28 | 0/11 |
| 8 | Aerosol | 1.00E+04 | Day 42 | 6/11* |
| 9 | Aerosol | 1.00E+04 | Day 56 | 4/12 |
| 10 | Aerosol | 1.00E+05 | Day 14 | 2/12 |
| 11 | Aerosol | 1.00E+05 | Day 28 | 2/12 |
| 12 | Aerosol | 1.00E+05 | Day 42 | 6/11 |
| 13 | Aerosol | 1.00E+05 | Day 56 | 4/11 |
| 14 | Aerosol | 5.00E+05 | Day 14 | 5/12** |
| 15 | Aerosol | 5.00E+05 | Day 28 | 7/11* |
| 16 | Aerosol | 5.00E+05 | Day 42 | 10/12* |
| 17 | Aerosol | 5.00E+05 | Day 56 | 7/12* |
| 18 | N/A | N/A | Day 56 | 0/12 |
| 19 | Intranasal | 1.00E+04 | Day 14 | 1/12 |
| 20 | Intranasal | 1.00E+04 | Day 28 | 2/12 |
| 21 | Intranasal | 1.00E+04 | Day 42 | 5/12* |
| 22 | Intranasal | 1.00E+04 | Day 56 | 2/12 |
N/A = not applicable.
* = Significantly greater than the number of positive blood cultures obtained from unchallenged mice.
**Significantly greater than the number of positive cultures obtained from unchallenged mice and mice challenged with 1.00 E+04 cfu on Day 14; Fisher's exact test p < 0.05.