Table 4. Incidence Summary of Brucella-related Microscopic Observations with Average Severity.
| Tissue/Observation | Number examineda (1.00E+04 cfu; aerosol) | Number observed | Average Severity | Number examineda (1.00E+05 cfu; aerosol) | Number observed | Average Severity | Number examineda (5.00E+05 cfu; aerosol) | Number observed | Average Severity | Number examineda (1.00E+04 cfu; intranasal) | Number observed | Average Severity |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver: Inflammation | 21 | 16 | 1.0 | 22 | 16 | 1.0 | 23 | 21 | 1.2 | 24 | 18 | 0.7 |
| Hematopoiesis | 21 | 5 | 0.3 | 22 | 5 | 0.3 | 23 | 2 | 0.1 | 24 | 2 | 0.1 |
| Infiltration of mononuclear cells | 21 | 2 | 0.1 | 22 | 0 | 0.0 | 23 | 0 | 0.0 | 24 | 0 | 0.0 |
| Lung: Inflammation | 21 | 11 | 0.5 | 22 | 9 | 0.4 | 23 | 15 | 0.7 | 24 | 8 | 0.4 |
| Mediastinal Lymph node: Infiltration of mononuclear cells, sinus | 20 | 5 | 0.3 | 16 | 4 | 0.3 | 20 | 8 | 0.7 | 21 | 1 | 0.0 |
| Hyperplasia, plasma cells | 20 | 6 | 0.4 | 16 | 4 | 0.2 | 20 | 10 | 0.6 | 21 | 3 | 0.0 |
| Spleen: Granulomatous inflammation | 21 | 9 | 0.6 | 22 | 16 | 1.0 | 23 | 17 | 1.1 | 24 | 12 | 0.7 |
| Increased extramedullary hematopoeisis | 21 | 13 | 0.6 | 22 | 13 | 0.8 | 23 | 16 | 0.9 | 24 | 9 | 0.4 |
| Heart: Epicardial inflammation | 21 | 1 | 0.1 | 22 | 3 | 0.2 | 23 | 6 | 0.3 | 24 | 4 | 0.2 |
| Kidney: Inflammation | 21 | 4 | 0.2 | 22 | 6 | 0.3 | 23 | 3 | 0.2 | 24 | 0 | 0.0 |
Lesions were graded on a scale of 1-4: 1, Minimal = least detectable lesion; 2, Mild, = Easily discemable lesion; 3, Moderate = Change affecting large area of represented tissues with potential to be relevant; 4, Marked = lesion that approached maximal.