Table 6.
Cox proportional hazards models for disease-specific 5-year survival in each decade, stratified by age.
| < 40 y HR (95% CI)1 |
40-59 y HR (95% CI)1 |
60-79 y HR (95% CI)1 |
80+ y HR (95% CI)1 |
Pinteraction2 | |
|---|---|---|---|---|---|
| Small intestine | |||||
| 2000s | 1.00 | 1.00 | 1.00 | 1.00 | |
| 1990s | 1.08 (0.27-4.24) | 1.36 (0.93-1.99) | 1.52 (1.21-1.92) | 1.29 (0.86-1.93) | |
| 1980s | 0.82 (0.13-4.95) | 1.42 (0.89-2.26) | 1.84 (1.41-2.41) | 1.55 (0.95-2.52) | |
| 1970s | 3.35 (0.72-15.6) | 2.16 (1.29-3.62) | 1.64 (1.15-2.35) | 1.38 (0.65-2.91) | |
| Ptrend | 0.306 | 0.003 | < 0.001 | 0.140 | 0.183 |
| Rectum | |||||
| 2000s | 1.00 | 1.00 | 1.00 | 1.00 | |
| 1990s | 0.26 (0.01-6.63) | 1.42 (0.85-2.37) | 1.56 (0.98-2.50) | 1.43 (0.35-5.86) | |
| 1980s | n/a | 1.61 (0.78-3.33) | 1.18 (0.65-2.14) | 0.78 (0.11-5.33) | |
| 1970s | n/a | 1.09 (0.24-4.91) | 1.27 (0.59-2.70) | n/a | |
| Ptrend | 0.123 | 0.173 | 0.177 | 0.718 | 0.711 |
| Stomach | |||||
| 2000s | 1.00 | 1.00 | 1.00 | 1.00 | |
| 1990s | n/a | 0.50 (0.22-1.11) | 1.30 (0.87-1.95) | 1.15 (0.51-2.60) | |
| 1980s | n/a | 0.77 (0.26-2.28) | 0.74 (0.38-1.42) | 1.57 (0.47-5.23) | |
| 1970s | n/a | 0.49 (0.12-1.97) | 1.38 (0.56-3.40) | 2.35 (0.39-14.3) | |
| Ptrend | n/a | 0.320 | 0.377 | 0.430 | 0.540 |
| Colon | |||||
| 2000s | 1.00 | 1.00 | 1.00 | 1.00 | |
| 1990s | 1.32 (0.38-4.56) | 1.22 (0.82-1.81) | 1.04 (0.82-1.31) | 1.04 (0.70-1.55) | |
| 1980s | n/a | 1.41 (0.86-2.30) | 1.08 (0.78-1.50) | 1.16 (0.70-1.92) | |
| 1970s | n/a | 1.81 (1.01-3.26) | 1.07 (0.72-1.61) | 1.33 (0.68-2.61) | |
| Ptrend | 0.796 | 0.009 | 0.195 | 0.396 | 0.786 |
Note: Appendiceal NETs were excluded from this analysis due to small numbers.
1 Adjusted for stage (localized vs. regional vs. distant), race/ethnicity (non-Hispanic white vs. Hispanic white vs. black vs. Native American vs. Asian), and registry site.
2 P value for interaction term between age (continuous) and year of diagnosis (continuous) in Cox proportional hazards model.