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. 2012 May 2;287(28):23283–23293. doi: 10.1074/jbc.M112.360347

FIGURE 2.

FIGURE 2.

Detailed views of the Ls- (A) or AcAChBP (B and C) binding sites are depicted. Principal face residues are colored blue, whereas complementary face residues are colored orange. Interacting residues are represented as sticks, and water molecules are shown as spheres. The nicotine-LsAChBP complex (PDB code 1UW6) (A), cytisine-AcAChBP complex (B), and varenicline-AcAChBP complex (C) are represented. D, shown is secondary structure matching superposition (53) of binding site principal faces of Ac-, Ls- (PDB code 1UW6), and BtAChBPs (PDB code 2BJ0, ligand omitted for clarity). Interesting, residues are represented as blue, silicon, and orange sticks, respectively, to outline the variability among the binding sites. For conserved residues, AcAChBP numbering is provided. E, shown is secondary structure matching superposition (53) of binding site principal faces of AcAChBP in complex with cytisine (blue) and varenicline (orange) and of LsAChBP in complex with nicotine (PDB code 1UW6). Interacting residues are represented as sticks to allow a comparison of binding modes for these ligands. For conserved residues, AcAChBP numbering is provided.