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Bar charts representing the improvement in binding affinity of selected mutants with respect to wild type AcAChBP (A) or to AcAChBP incorporating the Y53W mutation (B). Improvement in affinity was measured as the ratio of affinities (KD) of either wild type (A) or Y53W (B) AcAChBPs to those of other AcAChBP mutants. Errors were propagated from initial radioligand binding measurements (Table 2).
