. 2012 May 2;287(28):23283–23293. doi: 10.1074/jbc.M112.360347

TABLE 2.

Binding data of cytisine, varenicline, and nicotine are reported for α4β2 and α7 nAChRs and AcAChBP as well as nicotine binding data for LsAChBP (ITC data) and BtAChBP (ITC data)

ND, not determined.

Protein	Nicotine	Cytisine	Varenicline
α4β2 nAChR (K_i) (nm)	0.95^a	0.17^a	0.06^a
α7 nAChR (K_i) (nm)	6290^a	4200^a	322^a
AcAChBP (K_D) (nm)	835^b	1640^b	342^b
LsAChBP (K_D) (nm)	45^c	ND	ND
BtAChBP (K_D) (nm)	8^d	ND	ND

^a From Refs. 21 and 23.

^b ITC data, this study.

^c From Ref. 14.

^d From Ref. 15.