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. 2012 May 21;287(28):23294–23305. doi: 10.1074/jbc.M111.313684

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Pin1 regulates the expression of ECM and fibrogenic growth factors in primary lung Fb. Cells were treated as in Fig. 3A and analyzed for the expression of ECM and growth factors. A, mRNA for MMP2 and MMP3. Data are shown as increased mRNA (percentage) after TGF-β1 compared with respective untreated control. B, culture media from A were immunoblotted with anti-MMP-2, and the bioactivity was measured by zymography. C, mRNA for TIMP1 and TIMP4. Data are shown as increased mRNA (percentage) after TGF-β1 compared with respective untreated control. D, culture media from C were immunoblotted with anti-TIMP1. E and F, basal level of growth factor mRNA. Error bars, S.D. of 3–4 separate cultures in each group. Data are representative of at least five independent experiments *, p < 0.05 by Student's t test in a two-tailed analysis.