FIGURE 2.

ERK5 is primarily expressed in transiently amplifying progenitors and/or newborn neurons in the SGZ. A–W, representative confocal images of brain sections immunostained for ERK5 (green), GFAP (A–C and G) (white), and various other cellular markers (red) including Sox2 (D–G), BrdU (H–K), doublecortin (DCX) (L–O), NeuroD (P–S), and NeuN (T–W). Panel G represents the enlarged boxed areas in panels C and F. Similarly, images in panels K, O, S, and W are enlarged images of their corresponding boxed areas in panels J, N, R, and V. Scale bar in A represents 25 μm and applies to all images except the enlarged ones. Scale bar in G represents 10 μm and applies to K, O, S, and W. Dashed lines outline the SGZ layer of the dentate gyrus. X, quantification of marker-positive cells in total ERK5⁺ cell population along the SGZ. Data represent mean percentage of double- or triple-labeled cells.