FIGURE 2.

Plasma decay and hepatic uptake of HDL-PC are not affected by PEMT deficiency or liver-specific elimination of CTα. After intravenous injection of [³H]PC-HDL into Pemt^−/− and Ctα^−/− mice and their wild-type controls, plasma radioactivity was measured over a period of 24 h. A and B represent the decay curves of ³H from plasma in Pemt^−/− and Ctα^−/− mice and their controls, respectively. C and D show hepatic uptake of HDL-PC calculated as the product of the HDL-PC plasma pool and the fractional catabolic rates derived from the decay curves. Values represent means ± S.E. (error bars) (n = 4–6 per group).