FIGURE 2.

HIRA complex is required for cross-tolerance. The viability of the indicated cells following exposure to cross (acquired)-tolerance-inducible stress is shown. Results are the means of at least three independent experiments, and error bars represent S.E. A, B, and E, cells were subjected to 40 °C for 1 h (priming stress) and 25 mm H₂O₂ for another 1 h (severe stress). C, for oxidative and heat stresses, cells were subjected to 0.1 mm H₂O₂ for 1 h (priming stress) and 46 °C for another 1 h (severe stress). For osmotic and oxidative stresses, cells were subjected to 0.6 m KCl for 1 h (priming stress) and 25 mm H₂O₂ for another 1 h (severe stress). D, cells were subjected to 0.1 mm H₂O₂ for 1 h (priming stress) and 25 mm H₂O₂ for another 1 h (severe stress).